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Acknowledgements The authors would like to thank all the participants, investigators and trial site staff who were involved in the conduct of the trials

When his dose was reduced to 0.5 mg, the nodules resolved even faster within 24 hours

At Week 72, reductions in body weight were associated with decreases in insulin resistance, as indicated by HOMA2-IR, with both tirzepatide and semaglutide treatment

Both tirzepatide and semaglutide mimic the hormone GLP-1, but tirzepatide also mimics another hormone, glucose-dependent insulinotropic polypeptide (GIP), and this may further contribute to weight loss