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The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising

GHK-Cu modulates the expression of a large number of human genes studies using gene expression microarrays have identified over 4,000 genes whose expression is influenced by GHK-Cu, with effects spanning multiple functional categories including tissue remodeling, antioxidant defense, and growth factor signaling

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10.1186/1471-2164-11-648 BMC Genomics 22 EzakiB.GardnerR