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Compensatory overproduction of pancreatic islets and eventual development of hyperinsulinemia, result in elevated hepatic synthesis and accumulation of total cholesterol (TC) and elevated low-density lipoprotein (LDL) levels, leading to inactivation of the enzyme LDL lipase, which is critical for cholesterol clearance

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Jon Brudvig, PhD These new findings beautifully reframe metformins role not as a simple glucose-lowering drug, but as a metabolic rewiring agent targeting the gutbrain axis

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