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Although diet interventions in humans are difficult to maintain weight loss, mice respond to caloric restriction (CR) well

This approach reflects contemporary medical perspectives on sustainable weight management and reinforces the programs emphasis on consistency and oversight

Others switch to a higher concentration like 5mg/mL once they reach maintenance dosing to keep unit measurements more manageable, though this requires ordering a new vial mixed at the different strength

However, a recent study did not support this finding but rather attributed the increased risk of insulin resistance to the concomitant presence of metabolic dysfunctionassociated steatotic liver disease (MASLD) (81)