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Their ability to successfully accelerate and improve the quality of skin wound healing has been widely demonstrated in animal studies and clinical trials (Wu et al., 2007

Furthermore, because both berberine and ALA independently and aggressively lower blood glucose levels, combining them with prescription anti-diabetic medications (such as metformin, sulfonylureas, or exogenous insulin) drastically increases the risk of severe hypoglycemia

Other novel compounds, such as polydatin, that is extracted from a traditional Chinese herb Polygonum cuspidatum , are also proven to exert therapeutic potential in SLE via by restraining ROS and NETosis-mediated damage (44)

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