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While approved for type 2 diabetes, Tirzepatide has shown significant weight loss benefits in individuals without diabetes

268 Jun N-terminal kinase (JNK) inhibits CRTC3 activity by mediating their phosphorylation and cytoplasmic retention

While our recent report has shown that over 7% of all prescriptions are for GLP-1-based therapies ( 8 ), oral formulations may lower barriers to initiation by offering a non-injectable option that can be prescribed and managed in a broader range of clinical settings