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Indeed, since the pituitary has a substantial DRD2 reserve for PRL inhibition, and PRL response reaches the plateau at about 40% receptor occupancy in rat pituitary cells (87), the 60% reduction of DRD2 levels measured in prolactinomas and MMQ cells after FLNA knockdown might not entirely account for the loss of D2R effects on PRL release and cell proliferation (81)

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Elevated GH and IGF-1 can support follicular development and steroidogenesis, potentially increasing progesterone and estradiol levels that support implantation and early pregnancy

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