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Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE (2006) Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy

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treatment with 50 nmol/kg and stained for different pancreatic hormones (scale bar 50 m) (i)

In rodent studies , this has been associated with increased testosterone production and activation of endocrine processes