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However, despite these complications, several patients are older than the mean expected life expectancy for patients with vEDS 25 and 11 patients have not had any GI or vascular complications, although 4 of these 11 are pediatric patients

4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)