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For clinicians, we hope these findings may prompt a more thoughtful, individualized approach when considering these therapies in higher-risk patients who have both obesity and autoimmune disease. I am excited about the combination of medications for these diseases pairing medicines with known benefits to treat the autoimmune disease with a GLP-1RA, said Sheer

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The authors reported statistically significant mean reductions in body weight from baseline across the retatrutide dose groups relative to placebo, with gastrointestinal adverse events the most frequently reported findings, consistent with the incretin-agonist class