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NAC supplementation (600 mg/day) has been shown to improve flow-mediated dilation in patients with chronic heart failure in a small RCT (Andrews et al., J Am Coll Cardiol, 2001) [65]

2 Natural bioactive as multitarget therapeutics in metabolic and liver disorders Naturally occurring flavonoids help manage type 2 diabetes by modulating key glucose-metabolizing enzymes

For example, vitamin C, vitamin E, and selenium are antioxidants that can help support glutathione production and function, as well as protect against oxidative stress

Reperfusion injury is characterized by increased oxidative stress, which damages cardiomyocytes, endothelial cells, and the extracellular matrix [90]