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Who should not take GLP-1s GLP-1s in all forms are unsuitable for people who: are pregnant or breastfeeding do not meet the eligibility criteria have a family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) Medical Perspective Patients with needle phobia, a preference for pill-based routines, or good adherence to oral administration guidelines may be better suited to oral GLP-1 formulations like semaglutide (Rybelsus, Wegovy), which can enhance treatment acceptance and potentially offer strong glycemic or weight control
The situation may not stop at Canadas borders
In immortalised human airway epithelial cell lines (including bronchial epithelial cells) and human alveolar epitheliallike cells, GLP-1 receptor agonists reduced epithelial stress and inflammatory signalling, including downregulation of epithelial-derived cytokines, including IL-33 and thymic stromal lymphopoietin (TSLP), both of which are implicated in epithelialmesenchymal crosstalk and fibroblast recruitment in fibrotic lung disease [66,67,68]
Sawashita, H
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