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Neuropharmacology 51:789804 Brennan GP, Garcia-Curran MM, Patterson KP, Luo R, Baram TZ (2021) Multiple disruptions of glial-neuronal networks in epileptogenesis that follows prolonged febrile seizures

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When activated, monocytes and neutrophils actively engage in phagocytosis of MSU crystals, initiating an inflammatory response ( In renal pathologies, sUA stimulates inherent renal cells, including endothelial cells, vascular smooth muscle cells, and renal tubular cells, to upregulate or secrete high mobility group protein 1 (HMGB1), inflammatory cytokines, and chemokines

Compression : Wrapping the shoulder with an elastic bandage or compression stocking can help minimize the swelling and support the joint