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It is important to note that weight changes during menopause are multifactorial, influenced by hormonal shifts, ageing-related metabolic changes, and lifestyle factors

Graphical Abstract Keywords Insulin resistance, Lipid metabolism, Metabolic dysfunction-associated steatotic liver disease, MASLD, Oxidative stress, Silent information regulator 1, SIRT1, Therapeutic targeting Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition closely linked to metabolic abnormalities

Additionally, some lignans are substrates or inhibitors of key cytochrome P450 enzymes, including CYP2D6 and CYP2C9, potentially competing with other drugs for metabolism

PMID 26491374