The underlying mechanism of responsiveness generally entails structural destabilisation of the lipid bilayer upon exposure to a stimulus, which increases membrane permeability or causes vesicle disintegration, enabling the regulated and site-specific release of encapsulated substances
5.2 Therapeutic efficacy in animal models 5.2.1 Neurodegenerative disorders Several compounds have demonstrated significant therapeutic potential in animal models of neurodegenerative diseases, such as AD and PD (Carrera and Cacabelos, 2019)
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In addition, studies also demonstrated that the C677T polymorphism of MTHFR is associated with onset age of schizophrenia in a dose-dependent manner, such as increasing numbers of the mutant T allele is linked with early onset 50