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Istradefylline is an adenosine A2A receptor antagonist which was shown to reduce OFF-time ranging from 12 to 114 min in several trials and has been in clinical use to treat motor fluctuations in Japan for many years and more recently (2019) also received FDA approval [14, 146, 147]

In addition, the number of studies on the relationship between smoking cessation and vascular endothelial function is overwhelmingly small

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As it was previously mentioned the secondary outcome measures observed by the researchers included gastrocnemius muscle mass and foot flexion contractures