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[1] [2] It belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists , which were originally developed for type 2 diabetes management but have demonstrated significant efficacy in promoting weight loss

Previous studies have found that GLP-1Rs are expressed in various tissues, including the pancreatic islets, brain, dorsal root ganglia, and spinal cord [20, 40,41,42,43]

Unintentional weight loss, more likely driven by comorbid disease, excessively impacts metabolically active tissue over fat mass [45]

Whether and how SARS-CoV-2 infection induces loss of glycaemic control in patients who are at risk of developing diabetes mellitus is also unclear