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SARS-CoV-2 infection systemically activates metabolic pathways to enhance cellular viral replication capacity In the first step, we used scRNA-Seq data of samples from COVID-19 patients as input to our modeling workflow to predict viral replication capacity depending on cell type and disease severity 22

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GPX1-4 and GPX6 use selenocysteine as the active center to catalyze the reduction of H 2 O 2 or organic hydroperoxides to water or corresponding alcohols, thereby reducing their toxicity and maintaining redox balance