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Individuals with severe gastrointestinal problems such as gastroparesis (delayed stomach emptying) or a history of severe pancreatitis (inflammation of the pancreas) should not use tirzepatide, as it can aggravate these conditions

Other Targets and Future Outlook Some of the key tumorigenic signaling pathways associated with loss of Merlin, such as the Hippo signaling pathway and activation of the E3 ubiquitin ligase CRL4 DCAF1 , are not directly targetable with currently approved drugs, but of interest for future therapeutic development

doi: 10.1001/jama.2021.1831 20 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

Understanding this helps me optimize treatment protocols