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The higher dosage drives a more robust GH pulse, amplifying lipolysis in abdominal fat stores

Triptolide also increases the levels of malondialdehyde, iron and prostaglandin endoperoxide synthase 2, depletes GSH and GPX4, and causes significant mitochondria damage

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The mechanism by which this pathway inhibits lipid peroxidation may be based on the direct antioxidant function of BH 4 , selectively preventing the oxidation of phospholipids containing two unsaturated acyl chains [48]