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Early detection allows initiation of preventive strategies such as smoking cessation, supervised exercise programs, lipid-lowering and antiplatelet therapy, and blood pressure optimization measures shown to reduce both cardiovascular risk and limb complications [124]

However, they pose three significant risks for athletes: hypovolemia/dehydration from osmotic diuresis, an increased risk of hypoglycemia when used with insulin or sulfonylureas, and the potential for euglycemic DKA (74)