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Instruct patients to promptly discontinue JANUMET XR and contact their physician if persistent severe abdominal pain occurs [see Warnings and Precautions (5.2)]

Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition

20 units, 10 day pulse, 4 month pause, supervised cycle

This is where the concept of bioavailability the degree and rate at which a substance is absorbed into the living systembecomes critical