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doi: 10.1177/0269881119858306 166 PretzschCMVoinescuBLythgoeDHorderJMendezMAWichersRet al

Indeed, none of the patients discontinued the study medication because of treatment-related side effects

amygdalina leaves, administered at 2,000 mg/kg in an acute toxicity study, did not cause any morbidity, neurological, behavioral, autonomic, or physical changes in mice, and no deaths occurred

Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models