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Treatment Plan Standard Treatment : 1 nebulizer session Duration : 1530 minutes per session Frequency : 12 times per week as needed until symptoms improve Adjustments : Based on your response, lab findings or imaging results

phosphorylation of Thr806 in SPT5 and also in the CTD of RNAPII were decreased after CDK9 inhibition 80,87,88 , and modest changes in phosphorylation of Ser2 and Ser7 were detected upon longer ( 1 h) CDK12/13 inhibition 78,81,89,90,91,92,93,94,95 (Fig