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Finally, it is important to mention that despite the lack of differences between RPM and control-treated cows, clear changes were reported regarding maternal blood parameters, nutrient delivery through the placenta, in addition to positive effects on follicular and fetal development, and offsprings postnatal performance
224,225,226 Additionally, Klotho enhances insulin sensitivity in peripheral tissues, including muscle and adipose tissue, and has neuroprotective functions through the modulation of neuronal signaling pathways
Participants with fetal alcohol syndrome, serious neurological disorders, metabolic, psychiatric, cardiovascular, or endocrine system disorders were also excluded
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