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systemic symptoms are present in around half of cases, which may help distinguish it from gout (where fever is much less common)

Initiation of Pro-Survival Signaling ERK Pathway Activation NAC activates the Ras-extracellular-signal-regulated kinase (ERK) pathway, which is crucial for neuroprotection against amyloid-beta (A) toxicity

Neurotoxic manifestations include neurodevelopmental disorders (abnormal neural differentiation and demyelination), neurotransmitter disorders, etc