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For instance, capillarisation of LSECs, characterised by the loss of fenestrae and the development of a basement membrane, has been observed in liver diseases such as metabolic-associated steatohepatitis and AH.25 Inducing apoptosis in capillarised LSECs has been shown to reduce fibrosis and inflammation in murine models, highlighting the significance of maintaining LSEC integrity to prevent disease progression.25 One of the key regulators of redox homeostasis and inflammation in LSECs is TXNIP, which is significantly elevated in both patients and murine models of ALD.26 TXNIP modulates the inflammatory response and plays a pivotal role in ethanol-induced liver injury

147 Oxidative stress is a pivotal factor in COPD pathogenesis by inducing oxidative damage to lung tissue through oxygen free radicals which accelerates pulmonary function decline

"Arnold Schwarzenegger receives Honorary Doctorate from Ulster University Belfast"

Lavoie et al