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Pathophysiology Problematic (chronic) tobacco use (eg, tobacco use disorder) involves complex physiological and psychosocial mechanisms: Physiological (ie, dependency): Nicotine strongly binds nicotinic acetylcholine receptors (nAChRs), primarily in the mesolimbic dopamine pathway

McCartney began his career as a member of the Quarrymen in 1957, which evolved into the Beatles in 1960

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