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The primary role of this enzyme is to facilitate the fourth step in pyrimidine synthesis by converting dihydroorotate (DHO) into orotate ( Figure 1 )

doi: 10.3389/fonc.2025.1610886 Received 13 April 2025 Accepted 23 June 2025 Published 14 July 2025 Corrected 29 July 2025 Volume 15 - 2025 Edited by Sandip Patil, Shenzhen Childrens Hospital, China Reviewed by Md Tajmul, National Institute of Diabetes and Digestive and Kidney Diseases (NIH), United States Fnu Wahiduzzaman, St

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