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Since 1978, when ELISA was first described [2], it became the gold standard antigen-antibody detection assay in basic research of which some assays were further optimized for diagnostic purposes and became commercially available
Alternatively, continuous daily dosing for 12 weeks followed by a 4-week break is another common approach
In contrast, TIGAR overexpression or treatment with Fer-1, a ferroptosis inhibitor, significantly increases NADPH, GPX4, and GSH levels, reduces GSSG expression, and attenuates neuronal ferroptosis and neurological impairment
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