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Sensing the luminal and lamina propria environment, EECs not only react to bacterial structures like LPS through pattern recognition receptors (72, 81, 82), and bacterial metabolites such as SCFA and indole (83), but also express TNF receptor 1 (84)

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Bethel et al included the trials LEADER, SUSTAIN 6, EXSCEL, HARMONY, REWIND, and PIONEER-6 in their meta-analysis and found that GLP-1RAs were associated with DR