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Predictive Characteristics : Patients likely to see the best outcomes are typically younger with milder obesity and exhibit specific physiological traits such as high loop gain and severe upper-airway collapsibility

Oral semaglutide (Rybelsus) achieved approximately 1013% weight loss in controlled trials, while newer oral tirzepatide formulations are showing comparable or superior results

As a GLP-1 receptor agonist, it has shown significant and sustained weight loss in clinical studies, making it a preferred choice for managing obesity beyond lifestyle changes

The accumulation of misfolded proteins in the ER can trigger a stress response that leads to increased ROS production and inflammation, contributing to neuronal cell death (Pandey et al., 2019)