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Regional medicines optimisation committee (RMOC) guidance suggests that decisions regarding biologic treatments, whether in treatment nave patients or in those using sequential therapies , should be based on shared-decision making to ensure treatment is appropriate, safe and clinically and cost effective[68]

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Comhair SA, Thomassen MJ, Erzurum SC: Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke