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Regarding kidney hemodynamic changes, increased glomerular pressure, presenting as whole kidney hyperfiltration or as single nephron hyperfiltration, accelerates kidney function decline [1]

In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]