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Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio

The review of published data is not necessarily replete in absolute terms because only data of clinical relevance in the management of hyperpigmentation has been included

Here, we demonstrated that preferential accumulation of peroxidized phospholipids and loss of the antioxidant enzyme glutathione peroxidase 4 (GPX4) were responsible for vulnerability of midbrain dopaminergic neurons and progressive motor dysfunctions in a mouse model of PD