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Ultimately, transport across the BBB is an important step in the regulation of nutrient and metabolite movement between blood and the brain

Obstruction of the sigmoid colon by mass or cancer can lead to difficulty having bowel movements despite laxatives, and if severe enough, can also result in abdominal pain, nausea, and vomiting. Prevention Get regular, vigorous exercise

Patients should be counselled about common adverse effects including nausea, vomiting, diarrhoea, and constipation, which typically improve over time

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