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1, 2, 3, 4 Of these mechanisms, vasoconstriction induced by nicotine is a relatively rapid process

A large body of literature has demonstrated that such FosB induction in D1-type [nucleus accumbens] neurons increases an animal's sensitivity to drug as well as natural rewards and promotes drug self-administration, presumably through a process of positive reinforcement

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Compared with cigarette smokers , exclusive e-cigarette users had significantly lower levels of most biomarkers