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These side effects are frequent and often lead to patients lowering their dose or stopping the medication altogether

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For instance, the beta-lactam antibiotic ceftriaxone has shown to elevate EAAT transport levels in astrocytes, leading to glutamate clearance and neuronal protection 126

Structures of the glucagon receptor (GCGR), the closest homolog of GLP-1R, have revealed key differences between the peptide-free and peptide-bound states, including an interesting -sheet motif in the peptide-free structure comprised of the stalk region and extracellular loop 1 ( ECL1) 9,14