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Why Metformin Can Leave You Too Tired to Lose Weight If youve been on metformin for years, for insulin resistance, PCOS, or type 2 diabetes, and youre too drained to walk after dinner, cook at home, or stick with any weight-loss plan, a low vitamin B12 level could be part of why

Severe gastrointestinal issues can severely impact the quality of life, often requiring ongoing medical treatment for those affected

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They discovered that participants who were on PT-141 demonstrated significant erectile activity, while participants on placebo did not