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The clinical and nonclinical safety record was subsequently marshaled in support of a Generally Recognized as Safe (GRAS) determination for AOD9604 as a dietary ingredient, conditional on publication of the underlying safety data [7]
Insufficient human clinical trials have led to a lack of data to determine a safe dose
Additionally, it assists in metabolizing homocysteine, a compound linked with cardiovascular risks when present in excess
Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet
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