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40-42 For patients with large CMN, the risk of developing melanoma (cutaneous or extracutaneous) is estimated to be 5% over a lifetime, with approximately half of this risk during the first 5 years of life (eTable 361.2 )

J Cardiopulm Rehabil Prev

Who Should Consider GLP-1 Therapy FDA indications for weight loss require: BMI 30 (obesity), or BMI 27 (overweight) with at least one weight-related condition hypertension, type 2 diabetes, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or similar These thresholds set eligibility, but they don't answer the more important question: who benefits most

Semaglutide slows gastric emptying, which prolongs the sensation of fullness after meals