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The included reports, in chronological order, were ELIXA ( Table 1

4.2 Overcoming multidrug resistance in cancer cells Tumor drug resistance poses a considerable challenge in cancer treatment, attributable to mechanisms including the overexpression of efflux proteins, enhanced DNA repair capabilities, and evasion of apoptosis

The proposed mechanism is that MOTS-c interacts with the STAT3 transcription factor via its putative SH2 binding motif (YIFY region), thereby reducing STAT3s transcriptional activity and promoting myotube formation

The European recommended daily intake also varies by age, beginning at 1.5 g for infants and increasing to 4 g for adults, with slightly higher requirements during pregnancy and lactation (4.5 g and 5 g, respectively