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Fibroblast and keratinocyte cell models are among the most commonly used systems to investigate its involvement in tissue maintenance and regenerative processes

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Activation of Nrf2 by ARE Inducers A variety of chemicals, including phytochemicals and derivatives (CDDO, sulforaphane), therapeutics (oltipraz, auranofin), environmental agents (paraquat, arsenic), and endogenous chemicals [NO, 15d-PGJ 2 , nitro-fatty acids, and 4-hydroxynonenal (4-HNE)], induce ARE genes through Nrf2 (12, 52)