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On the other hand, stimulation of the P2Y13 receptors by ADP increases the activity of heme oxygenase-1 (HO-1), an enzyme involved in cytoprotection [47]

Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K(+) Channels in beta Cells

Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)

Moreover, stimulation of LS GLP-1R neurons reduced food intake, both in an acute and chronic manner, while inhibition increased food intake [108,109]