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Maintaining gradual weight loss, adequate protein intake (RDA 0.8 g/kg daily, with higher intakes of 1.2-1.6 g/kg potentially beneficial during weight loss unless contraindicated by kidney disease), resistance exercise, and skin hydration may optimize skin adaptation during weight reduction

Similarly, those taking certain diabetes or blood pressure medications may experience compounded side effects

[3] The exact structure of the compound was not known at the time, although it was known to crystallize as a monohydrate

Skin symptoms Reddish, thickened skin (Graves' dermopathy) Rough skin texture, primarily on the shins Mild and painless in most cases 3