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DAS transiently increases ROS concentrations stimulating, ERK and P38 MAP kinase which phosphorylate Nrf2 [203, 220]

The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)

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The compound melanocytic nevus includes both a junctional component and the infiltration of the dermis by nevus cells distributed singly and in nests