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For instance, metformin, a widely prescribed medication for managing type 2 diabetes, finds its roots in the French lilac plant (Galega officinalis)

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Disruption of the BBB including compromised BBB integrity and subsequent leakage of plasma constituents into the brain parenchyma, and impaired BBB dysfunction consisting of compromised transport system, reduced CBF, and heightened vascular inflammatory response at the BBB level, which are closely interlinked with the accumulation of A and the presence of neurofibrillary tangles [137]

Genistein has a higher binding affinity for ER than ER and its activity depends on endogenous estrogen levels and ER expression (Irrera et al., 2017