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A 2024 review in Cartilage identified AOD-9604 among key peptides recognized for benefits to bone and joint health, noting its capacity for chondrogenic induction and cartilage regeneration in osteoarthritis models

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Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)