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For instance, food-based dietary guidelines could be updated to include specific, mechanism-aware advice, such as recommending one serving of cruciferous vegetables three to four times per week to leverage Nrf2 activation, or promoting the inclusion of fermented foods like yogurt or kimchi to support gut health via microbial metabolites
Results Emulating pivotal cardiovascular outcome trials and expanding populations To validate our analytical framework, we emulated the cardiovascular outcome trials SUSTAIN-6 and SURPASS-CVOT using three national claims databases from the USA
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Our findings provide evidence that pharmacological approaches to increase endogenous GLP1 could be a useful adjunct approach to reduce acute olanzapine-induced perturbations in lipid and glucose metabolism
