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Studies have shown that Sal attenuates acute hypobaric hypoxia-induced brain oxidative stress injury, inflammatory response, and BBB damage ( Our teams previous study found that polysaccharide extracted from Potentilla anserina L could inhibit oxidative stress and inflammatory responses to treat and prevent HACE and HAPE, and its mechanism of action may be to block the activation of the NF-B and HIF-1 signaling pathways, which inhibits the production of downstream pro-inflammatory cytokines (IL-1, IL-6, TNF-, and VEGF) (Shi et al., 2019

The incidence rate is the highest among children and adolescents, with a higher rate in males than in females